The Drug Enforcement Administration is warning the public about a growing danger in the illegal drug supply involving fentanyl mixed with other powerful synthetic drugs.

Officials say fentanyl is now being found with other substances such as xylazine, medetomidine, and nitazenes, according to a public safety advisory issued Tuesday.

These drugs are often not meant for human use, and many people do not know they are taking them, the DEA said.

Some of these drugs are used by veterinarians to sedate animals, while others are illegal synthetic opioids made in labs. The DEA says these combinations make street drugs even more unpredictable and much more deadly.

According to the agency, some of these substances can be stronger than fentanyl itself. They are often pressed into fake pills or mixed into powders, so users may not know what is really inside.

Officials also warn that overdose-reversal drugs like naloxone (Narcan) may not always fully work, especially when drugs like xylazine are involved. In some cases, multiple doses may be needed.

The DEA says these drugs can cause serious harm, including slowed breathing, loss of consciousness, severe infections, and death.

Health and law enforcement officials are urging people to avoid any illegal drugs, warning that even one pill can be deadly. They also encourage people to carry naloxone if possible and to call 911 immediately if someone may be overdosing.

More information is available here.